Version 5.4
Mus musculus Gene: Cyp27a1
Summary
InnateDB Gene IDBG-168561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyp27a1
Gene Name cytochrome P450, family 27, subfamily a, polypeptide 1
Synonyms 1300013A03Rik; Cyp27
Species Mus musculus
Ensembl Gene ENSMUSG00000026170
Encoded Proteins
IDBP-168563
cytochrome P450, family 27, subfamily a, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135929:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74713574-74737892
Strand Forward strand
Band C4
Transcripts
ENSMUST00000027356 ENSMUSP00000027356
ENSMUST00000190781
ENSMUST00000189083
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0030343 vitamin D3 25-hydroxylase activity
GO:0031073 cholesterol 26-hydroxylase activity
GO:0047749 cholestanetriol 26-monooxygenase activity
Biological Process
GO:0008203 cholesterol metabolic process
GO:0036378 calcitriol biosynthetic process from calciol
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135929
View Gene Order
ENSBTAG00000013489
Not yet available
Pathways
NETPATH
REACTOME
REACT_232159
Cytochrome P450 - arranged by substrate type pathway
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_210229
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_227038
Endogenous sterols pathway
REACT_207530
Synthesis of bile acids and bile salts pathway
REACT_203193
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_232343
Biological oxidations pathway
REACT_226440
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_229469
Bile acid and bile salt metabolism pathway
KEGG
mmu00120
Primary bile acid biosynthesis pathway
mmu03320
PPAR signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11053
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
REACT_11041
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_11048
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_13812
Endogenous sterols pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa03320
PPAR signaling pathway pathway
hsa00120
Primary bile acid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.85083
RefSeq NM_024264
OMIM
CCDS CCDS15054
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca