Version 5.4
Mus musculus Protein: Cyp27a1
Summary
InnateDB Protein IDBP-168563.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyp27a1
Protein Name cytochrome P450, family 27, subfamily a, polypeptide 1
Synonyms 1300013A03Rik; Cyp27;
Species Mus musculus
Ensembl Protein ENSMUSP00000027356
InnateDB Gene IDBG-168561 (Cyp27a1)
Protein Structure
UniProt Annotation
Function Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0030343 vitamin D3 25-hydroxylase activity
GO:0031073 cholesterol 26-hydroxylase activity
GO:0047749 cholestanetriol 26-monooxygenase activity
Biological Process
GO:0008203 cholesterol metabolic process
GO:0036378 calcitriol biosynthetic process from calciol
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005743 mitochondrial inner membrane
Protein Structure and Domains
PDB ID MGI:88594
InterPro IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DBG1
PhosphoSite PhosphoSite-Q9DBG1
TrEMBL Q99LX3
UniProt Splice Variant
Entrez Gene 104086
UniGene Mm.85083
RefSeq NP_077226
MGI ID
MGI Symbol Cyp27a1
OMIM
CCDS CCDS15054
HPRD
IMGT
EMBL AK004977 BC002183 BC055028
GenPept AAH02183 AAH55028 BAB23713

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca