InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Canx

Summary

InnateDB Gene

IDBG-168591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Canx

Gene Name

calnexin

Synonyms

1110069N15Rik; AI988026; Cnx; D11Ertd153e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020368

Encoded Proteins

IDBP-168593

calnexin

IDBP-718519

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127022:
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:50293961-50325673

Strand

Reverse strand

Band

B1.3

Transcripts

ENSMUST00000020637	ENSMUSP00000020637
ENSMUST00000146979
ENSMUST00000153068
ENSMUST00000155801
ENSMUST00000179865	ENSMUSP00000137440

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0034185	apolipoprotein binding
GO:0035255	ionotropic glutamate receptor binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007568	aging
GO:0048488	synaptic vesicle endocytosis
GO:0061077	chaperone-mediated protein folding
GO:0072583	clathrin-mediated endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005840	ribosome
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0032839	dendrite cytoplasm
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane