Version 5.4
Mus musculus Gene: Rufy1
Summary
InnateDB Gene IDBG-168794.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rufy1
Gene Name RUN and FYVE domain containing 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020375
Encoded Proteins
IDBP-168796
RUN and FYVE domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176783:
This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:50389286-50431125
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000020643 ENSMUSP00000020643
ENSMUST00000135508
ENSMUST00000129304
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0008565 protein transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0030100 regulation of endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000176783
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.390400
RefSeq NM_172557 XM_006532841
OMIM
CCDS CCDS24635
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca