Version 5.4
Mus musculus Protein: Rufy1
Summary
InnateDB Protein IDBP-168796.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rufy1
Protein Name RUN and FYVE domain containing 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000020643
InnateDB Gene IDBG-168794 (Rufy1)
Protein Structure
UniProt Annotation
Function Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. {ECO:0000269PubMed:11172003, ECO:0000269PubMed:16522682}.
Subcellular Localization Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity Broadly expressed. {ECO:0000269PubMed:11172003}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0008565 protein transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0030100 regulation of endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:2429762
InterPro IPR000306 FYVE zinc finger
IPR004012 RUN
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF01363
PF02759
PRINTS
PIRSF
SMART SM00064
SM00593
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BIJ7
PhosphoSite PhosphoSite-Q8BIJ7
TrEMBL
UniProt Splice Variant
Entrez Gene 216724
UniGene Mm.390400
RefSeq NP_766145
MGI ID
MGI Symbol Rufy1
OMIM
CCDS CCDS24635
HPRD
IMGT
EMBL AJ250024 AK046625 AK046633 AK051178 AL645904
GenPept BAC32811 BAC32815 BAC34548 CAC17732 CAI24002

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca