InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adamts2

Summary

InnateDB Gene

IDBG-168907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adamts2

Gene Name

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036545

Encoded Proteins

IDBP-168909

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087116:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:50602084-50807573

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000040523	ENSMUSP00000040171
ENSMUST00000125988
ENSMUST00000127534
ENSMUST00000142118

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008233	peptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007283	spermatogenesis
GO:0016485	protein processing
GO:0030199	collagen fibril organization
GO:0030324	lung development
GO:0030574	collagen catabolic process
GO:0043588	skin development