InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADAMTS2

Summary

InnateDB Gene

IDBG-641136.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS2

Gene Name

A disintegrin and metalloproteinase with thrombospondin motifs 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014665

Encoded Proteins

IDBP-693464

A disintegrin and metalloproteinase with thrombospondin motifs 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087116:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:1956352-2165242

Strand

Forward strand

Band

Transcripts

ENSBTAT00000019526

ENSBTAP00000019526

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0007283	spermatogenesis
GO:0016485	protein processing
GO:0030199	collagen fibril organization
GO:0030324	lung development
GO:0030574	collagen catabolic process
GO:0032964	collagen biosynthetic process
GO:0043206	extracellular fibril organization
GO:0043588	skin development