Version 5.4
Mus musculus Gene: Aplp1
Summary
InnateDB Gene IDBG-168935.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aplp1
Gene Name amyloid beta (A4) precursor-like protein 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000006651
Encoded Proteins
IDBP-168937
amyloid beta (A4) precursor-like protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105290:
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30434981-30445582
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000006828 ENSMUSP00000006828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0031694 alpha-2A adrenergic receptor binding
GO:0031695 alpha-2B adrenergic receptor binding
GO:0031696 alpha-2C adrenergic receptor binding
GO:0042802 identical protein binding
GO:0046914 transition metal ion binding
Biological Process
GO:0006378 mRNA polyadenylation
GO:0006417 regulation of translation
GO:0006897 endocytosis
GO:0006915 apoptotic process
GO:0007155 cell adhesion
GO:0030198 extracellular matrix organization
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0030900 forebrain development
GO:0071874 cellular response to norepinephrine stimulus
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105290
View Gene Order
ENSBTAG00000001151
Not yet available
Cross-References
SwissProt Q03157
TrEMBL
UniProt Splice Variant
Entrez Gene 11803
UniGene Mm.474009
RefSeq NM_007467
OMIM
CCDS CCDS21092
HPRD
IMGT
MGI ID MGI:88046
MGI Symbol Aplp1
EMBL BC021877 L04538
GenPept AAA37247 AAH21877
RNA Seq Atlas 11803

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca