Version 5.4
Homo sapiens Gene: APLP1
Summary
InnateDB Gene IDBG-45875.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APLP1
Gene Name amyloid beta (A4) precursor-like protein 1
Synonyms APLP
Species Homo sapiens
Ensembl Gene ENSG00000105290
Encoded Proteins
IDBP-45877
amyloid beta (A4) precursor-like protein 1
IDBP-597839
amyloid beta (A4) precursor-like protein 1
IDBP-764461
IDBP-813199
amyloid beta (A4) precursor-like protein 1
IDBP-762495
IDBP-765850
IDBP-763274
IDBP-763358
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35867899-35879791
Strand Forward strand
Band q13.12
Transcripts
ENST00000221891 ENSP00000221891
ENST00000537454 ENSP00000441501
ENST00000589298
ENST00000589743 ENSP00000466116
ENST00000587274 ENSP00000474762
ENST00000591165
ENST00000590926
ENST00000588808 ENSP00000466576
ENST00000586861 ENSP00000465694
ENST00000592316 ENSP00000467854
ENST00000590561 ENSP00000466623
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 70 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0031694 alpha-2A adrenergic receptor binding
GO:0031695 alpha-2B adrenergic receptor binding
GO:0031696 alpha-2C adrenergic receptor binding
GO:0042802 identical protein binding
GO:0046914 transition metal ion binding
Biological Process
GO:0006378 mRNA polyadenylation
GO:0006417 regulation of translation
GO:0006897 endocytosis
GO:0006915 apoptotic process
GO:0007155 cell adhesion
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007399 nervous system development
GO:0009887 organ morphogenesis
GO:0030198 extracellular matrix organization
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0030900 forebrain development
GO:0071874 cellular response to norepinephrine stimulus
Cellular Component
GO:0005604 basement membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006651
View Gene Order
ENSBTAG00000001151
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.613814 Hs.74565
RefSeq NM_001024807 NM_005166
HUGO
OMIM
CCDS CCDS32997
HPRD 00102
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca