InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SEC61G

Summary

InnateDB Gene

IDBG-16894.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC61G

Gene Name

Sec61 gamma subunit

Synonyms

SSS1

Species

Homo sapiens

Ensembl Gene

ENSG00000132432

Encoded Proteins

IDBP-16896

Sec61 gamma subunit

IDBP-239368

Sec61 gamma subunit

IDBP-375583

Sec61 gamma subunit

IDBP-375586

Sec61 gamma subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:54752250-54759974

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000352861	ENSP00000341538
ENST00000395535	ENSP00000378906
ENST00000415949	ENSP00000388337
ENST00000450622	ENSP00000409884
ENST00000460484
ENST00000480303
ENST00000461536

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008565	protein transporter activity
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006412	translation
GO:0006605	protein targeting
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006886	intracellular protein transport
GO:0010467	gene expression
GO:0015031	protein transport
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0044267	cellular protein metabolic process
GO:0045047	protein targeting to ER
GO:0071806	protein transmembrane transport

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000078974

View Gene Order

ENSBTAG00000014971

Not yet available

Pathways

NETPATH

REACTOME

REACT_111178

ER-Phagosome pathway pathway

REACT_115902

SRP-dependent cotranslational protein targeting to membrane pathway

REACT_1014

Translation pathway

REACT_111119

Antigen processing-Cross presentation pathway

REACT_17015

Metabolism of proteins pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

REACT_71

Gene Expression pathway

KEGG

hsa05110

Vibrio cholerae infection pathway

hsa03060

Protein export pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

P60059

TrEMBL

A0A024QYZ0

UniProt Splice Variant

Entrez Gene

23480

UniGene

RefSeq

NM_014302 NM_001012456

HUGO

HGNC:18277

OMIM

609215

CCDS

CCDS5513

HPRD

15318

IMGT

EMBL

AF054184 AK311845 BC009480 BC051840 CH471201 CR456979

GenPept

AAC99401 AAH09480 AAH51840 BAG34787 CAG33260 EAW50960 EAW50961

RNA Seq Atlas

23480