InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grm6

Summary

InnateDB Gene

IDBG-169115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm6

Gene Name

glutamate receptor, metabotropic 6

Synonyms

BC021919; Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3; nob4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000617

Encoded Proteins

IDBP-169117

glutamate receptor, metabotropic 6

IDBP-622481

glutamate receptor, metabotropic 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113262:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:50850685-50866208

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000000631	ENSMUSP00000000631
ENSMUST00000156890
ENSMUST00000126890
ENSMUST00000171427	ENSMUSP00000130728

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007601	visual perception
GO:0007626	locomotory behavior
GO:0050908	detection of light stimulus involved in visual perception
GO:0050953	sensory perception of light stimulus
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060041	retina development in camera-type eye
GO:0090280	positive regulation of calcium ion import

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0035841	new growing cell tip
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane