InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grm6

Summary

InnateDB Protein

IDBP-622481.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm6

Protein Name

glutamate receptor, metabotropic 6

Synonyms

BC021919; Gm3; Gprc1f; mGluR6; nerg1; nob2; nob3; nob4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130728

InnateDB Gene

IDBG-169115 (Grm6)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. {ECO:0000250, ECO:0000269PubMed:22131384, ECO:0000269PubMed:9144650}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane (By similarity). Detected at dendritic tips of bipolar cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in the outer plexiform layer in retina (at protein level). {ECO:0000269PubMed:18001285, ECO:0000269PubMed:7889569}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007601	visual perception
GO:0007626	locomotory behavior
GO:0050908	detection of light stimulus involved in visual perception
GO:0050953	sensory perception of light stimulus
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060041	retina development in camera-type eye
GO:0090280	positive regulation of calcium ion import

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0035841	new growing cell tip
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1351343

InterPro

IPR000112 GPCR, family 3, metabotropic glutamate receptor 6
IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000337 GPCR, family 3
IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR01056
PR00593
PR00248
PR01054

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5NCH9