Version 5.4
Mus musculus Gene: Prr5
Summary
InnateDB Gene IDBG-169606.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prr5
Gene Name proline rich 5 (renal)
Synonyms Arhgap8; AU043908; C030017C09Rik; C78947; Protor-1; Protor1
Species Mus musculus
Ensembl Gene ENSMUSG00000036106
Encoded Proteins
IDBP-169612
proline rich 5 (renal)
IDBP-623909
proline rich 5 (renal)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186654:
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:84669620-84703673
Strand Forward strand
Band E2
Transcripts
ENSMUST00000065499 ENSMUSP00000066396
ENSMUST00000171460 ENSMUSP00000127890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007049 cell cycle
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Cellular Component
GO:0031932 TORC2 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186654
View Gene Order
ENSBTAG00000039784
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
Cross-References
SwissProt Q812A5
TrEMBL
UniProt Splice Variant
Entrez Gene 109270
UniGene Mm.488156
RefSeq NM_146061 XM_006520278 XM_006520280 XM_006520281
OMIM
CCDS CCDS27711
HPRD
IMGT
MGI ID MGI:1924714
MGI Symbol Prr5
EMBL AF482997 AK046057 AK081231 BC024991 BK005634
GenPept AAH24991 AAO39849 BAC32586 BAC38171 DAA05653
RNA Seq Atlas 109270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca