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InnateDB Protein
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IDBP-623909.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Prr5
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Protein Name
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proline rich 5 (renal)
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Synonyms
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Arhgap8; AU043908; C030017C09Rik; C78947; Protor-1; Protor1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000127890
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InnateDB Gene
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IDBG-169606 (Prr5)
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Protein Structure
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| Function |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity). {ECO:0000250}.
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
Ubiquitously expressed. Expressed at high levels in kidney. {ECO:0000269PubMed:12559566}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
2
[view]
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| Protein-Protein |
2
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
12 [view]
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Molecular Function |
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| Biological Process |
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GO:0001934
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positive regulation of protein phosphorylation
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GO:0007049
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cell cycle
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GO:0014068
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positive regulation of phosphatidylinositol 3-kinase signaling
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| Cellular Component |
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| PDB ID |
MGI:1924714
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| InterPro |
IPR013745
HbrB-like
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| PFAM |
PF08539
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q812A5
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| PhosphoSite |
PhosphoSite-Q812A5
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
109270
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| UniGene |
Mm.488156
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| RefSeq |
XP_006520341
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| MGI ID |
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| MGI Symbol |
Prr5
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AF482997
AK046057
AK081231
BC024991
BK005634
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| GenPept |
AAH24991
AAO39849
BAC32586
BAC38171
DAA05653
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Version 5.4