InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Neil1

Summary

InnateDB Gene

IDBG-169720.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Neil1

Gene Name

nei endonuclease VIII-like 1 (E. coli)

Synonyms

2810450N13Rik; Nei1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032298

Encoded Proteins

IDBP-169722

nei endonuclease VIII-like 1 (E. coli)

IDBP-787534

nei endonuclease VIII-like 1 (E. coli)

IDBP-787535

nei endonuclease VIII-like 1 (E. coli)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140398:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:57142800-57148305

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034842	ENSMUSP00000034842
ENSMUST00000190245	ENSMUSP00000139917
ENSMUST00000186410	ENSMUSP00000141048

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003684	damaged DNA binding
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0008022	protein C-terminus binding
GO:0008270	zinc ion binding
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829	lyase activity
GO:0019104	DNA N-glycosylase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006979	response to oxidative stress
GO:0032074	negative regulation of nuclease activity

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000140398

View Gene Order

ENSBTAG00000007365

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03410

Base excision repair pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa03410

Base excision repair pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

72774

UniGene

RefSeq

XM_006511484 XM_006511485 XM_006511486 NM_028347

OMIM

CCDS

CCDS23217

HPRD

IMGT

MGI ID

MGI:1920024

MGI Symbol

Neil1

EMBL

AB079069 AK013322 BC043297

GenPept

AAH43297 BAB28790 BAC06477

RNA Seq Atlas

72774