InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Neil1

Summary

InnateDB Protein

IDBP-787535.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Neil1

Protein Name

nei endonuclease VIII-like 1 (E. coli)

Synonyms

2810450N13Rik; Nei1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000141048

InnateDB Gene

IDBG-169720 (Neil1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003684	damaged DNA binding
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0008022	protein C-terminus binding
GO:0008270	zinc ion binding
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829	lyase activity
GO:0019104	DNA N-glycosylase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006979	response to oxidative stress
GO:0032074	negative regulation of nuclease activity

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center

Protein Structure and Domains

PDB ID

MGI:1920024

InterPro

IPR010979 Ribosomal protein S13-like, H2TH
IPR012319 DNA glycosylase/AP lyase, catalytic domain
IPR015371 Endonuclease VIII-like 1, DNA binding
IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding

PFAM

PF01149
PF09292
PF06831

PRINTS

PIRSF

SMART

SM00898

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

72774

UniGene

RefSeq

MGI ID

MGI Symbol

Neil1

OMIM

CCDS

CCDS23217

HPRD

IMGT

EMBL

AB079069 AK013322 BC043297

GenPept

AAH43297 BAB28790 BAC06477