InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ednra

Summary

InnateDB Gene

IDBG-169763.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ednra

Gene Name

endothelin receptor type A

Synonyms

ET-AR; ETa; Gpcr10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031616

Encoded Proteins

IDBP-169765

endothelin receptor type A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151617:
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:77663031-77724464

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034029	ENSMUSP00000034029
ENSMUST00000146561

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004962	endothelin receptor activity
GO:0005515	protein binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001821	histamine secretion
GO:0001934	positive regulation of protein phosphorylation
GO:0003094	glomerular filtration
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007266	Rho protein signal transduction
GO:0007507	heart development
GO:0007568	aging
GO:0007585	respiratory gaseous exchange
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0014032	neural crest cell development
GO:0014070	response to organic cyclic compound
GO:0014824	artery smooth muscle contraction
GO:0015758	glucose transport
GO:0019233	sensory perception of pain
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032496	response to lipopolysaccharide
GO:0042310	vasoconstriction
GO:0042482	positive regulation of odontogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043084	penile erection
GO:0043278	response to morphine
GO:0048144	fibroblast proliferation
GO:0048484	enteric nervous system development
GO:0048659	smooth muscle cell proliferation
GO:0050678	regulation of epithelial cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928	positive regulation of calcium ion transport
GO:0060137	maternal process involved in parturition
GO:0060322	head development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071260	cellular response to mechanical stimulus
GO:0086100	endothelin receptor signaling pathway
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0090184	positive regulation of kidney development