InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ednra

Summary

InnateDB Protein

IDBP-169765.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ednra

Protein Name

endothelin receptor type A

Synonyms

ET-AR; ETa; Gpcr10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034029

InnateDB Gene

IDBG-169763 (Ednra)

Protein Structure

UniProt Annotation

Function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004962	endothelin receptor activity
GO:0005515	protein binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001821	histamine secretion
GO:0001934	positive regulation of protein phosphorylation
GO:0003094	glomerular filtration
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007266	Rho protein signal transduction
GO:0007507	heart development
GO:0007568	aging
GO:0007585	respiratory gaseous exchange
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0014032	neural crest cell development
GO:0014070	response to organic cyclic compound
GO:0014824	artery smooth muscle contraction
GO:0015758	glucose transport
GO:0019233	sensory perception of pain
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032496	response to lipopolysaccharide
GO:0042310	vasoconstriction
GO:0042482	positive regulation of odontogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043084	penile erection
GO:0043278	response to morphine
GO:0048144	fibroblast proliferation
GO:0048484	enteric nervous system development
GO:0048659	smooth muscle cell proliferation
GO:0050678	regulation of epithelial cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928	positive regulation of calcium ion transport
GO:0060137	maternal process involved in parturition
GO:0060322	head development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071260	cellular response to mechanical stimulus
GO:0086100	endothelin receptor signaling pathway
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0090184	positive regulation of kidney development

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0031965	nuclear membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:105923

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000499 Endothelin receptor family
IPR002175 Endothelin receptor A
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00366
PR00570

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61614