Version 5.4
Mus musculus Gene: Clk4
Summary
InnateDB Gene IDBG-169801.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clk4
Gene Name CDC like kinase 4
Synonyms AI987988; C85119
Species Mus musculus
Ensembl Gene ENSMUSG00000020385
Encoded Proteins
IDBP-169807
CDC like kinase 4
IDBP-263076
CDC like kinase 4
IDBP-263078
CDC like kinase 4
IDBP-537382
CDC like kinase 4
IDBP-532508
CDC like kinase 4
IDBP-533138
CDC like kinase 4
IDBP-532039
CDC like kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113240:
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:51261730-51281766
Strand Forward strand
Band B1.3
Transcripts
ENSMUST00000093132 ENSMUSP00000090820
ENSMUST00000109113 ENSMUSP00000104741
ENSMUST00000109111 ENSMUSP00000104739
ENSMUST00000153414 ENSMUSP00000115894
ENSMUST00000130641 ENSMUSP00000123133
ENSMUST00000126131 ENSMUSP00000118972
ENSMUST00000133200
ENSMUST00000136587
ENSMUST00000148053 ENSMUSP00000120822
ENSMUST00000146776
ENSMUST00000148467
ENSMUST00000140628
ENSMUST00000147007
ENSMUST00000143468
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043484 regulation of RNA splicing
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113240
View Gene Order
ENSBTAG00000019414
Not yet available
Cross-References
SwissProt O35493
TrEMBL
UniProt Splice Variant
Entrez Gene 12750
UniGene Mm.239354 Mm.410214 Mm.471998
RefSeq XM_006532114 XM_006532115 XM_006532116 XM_006532117 NM_007714 XM_006532118
OMIM
CCDS CCDS24651
HPRD
IMGT
MGI ID MGI:1098551
MGI Symbol Clk4
EMBL AF033566 AK013974 BC002220 BC012675 U94846
GenPept AAB62179 AAB87510 AAH02220 AAH12675 BAC25420
RNA Seq Atlas 12750

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca