Version 5.4
Mus musculus Protein: Clk4
Summary
InnateDB Protein IDBP-263078.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clk4
Protein Name CDC like kinase 4
Synonyms AI987988; C85119;
Species Mus musculus
Ensembl Protein ENSMUSP00000104739
InnateDB Gene IDBG-169801 (Clk4)
Protein Structure
UniProt Annotation
Function Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269PubMed:11461155, ECO:0000269PubMed:9307018}.
Subcellular Localization Nucleus {ECO:0000269PubMed:9307018}.
Disease Associations
Tissue Specificity Expressed in the hippocampus, the cerebellum and the olfactory bulb. {ECO:0000269PubMed:12169693}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043484 regulation of RNA splicing
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1098551
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35493
PhosphoSite PhosphoSite-O35493
TrEMBL
UniProt Splice Variant
Entrez Gene 12750
UniGene Mm.471998
RefSeq
MGI ID
MGI Symbol Clk4
OMIM
CCDS
HPRD
IMGT
EMBL AF033566 AK013974 BC002220 BC012675 U94846
GenPept AAB62179 AAB87510 AAH02220 AAH12675 BAC25420

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca