InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pou4f2

Summary

InnateDB Gene

IDBG-169952.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pou4f2

Gene Name

POU domain, class 4, transcription factor 2

Synonyms

Brn-3.2; Brn-3b; Brn3b; mBrn3-3R; Pou4f-rs1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031688

Encoded Proteins

IDBP-169954

POU domain, class 4, transcription factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151615:
The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:78433010-78436645

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034115

ENSMUSP00000034115

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007605	sensory perception of sound
GO:0030182	neuron differentiation
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0031290	retinal ganglion cell axon guidance
GO:0045597	positive regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048675	axon extension
GO:0050885	neuromuscular process controlling balance
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0005634	nucleus
GO:0016607	nuclear speck

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000151615

View Gene Order

ENSBTAG00000005648

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

Q63934

TrEMBL

UniProt Splice Variant

Entrez Gene

18997

UniGene

Mm.234261

RefSeq

NM_138944

OMIM

CCDS

CCDS22429

HPRD

IMGT

MGI ID

MGI:102524

MGI Symbol

Pou4f2

EMBL

AK087546 S68377 S69351

GenPept

AAB30578 AAC60672 BAC39921

RNA Seq Atlas

18997