InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pou4f2

Summary

InnateDB Protein

IDBP-169954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pou4f2

Protein Name

POU domain, class 4, transcription factor 2

Synonyms

Brn-3.2; Brn-3b; Brn3b; mBrn3-3R; Pou4f-rs1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034115

InnateDB Gene

IDBG-169952 (Pou4f2)

Protein Structure

UniProt Annotation

Function

Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons. {ECO:0000269PubMed:7904822}.

Subcellular Localization

Nucleus speckle {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000255PROSITE-ProRule:PRU00530}.

Disease Associations

Tissue Specificity

Brain, peripheral sensory nervous system and retina. In the adult nervous system BRN-3.2 predominates in the optical, intermediate, and deep gray areas of the superior colliculus, the dorsal column of the mesencephalic and pontine central gray, and the lateral interpeduncular nucleus. {ECO:0000269PubMed:7904822}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007605	sensory perception of sound
GO:0030182	neuron differentiation
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0031290	retinal ganglion cell axon guidance
GO:0045597	positive regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048675	axon extension
GO:0050885	neuromuscular process controlling balance
GO:0060041	retina development in camera-type eye