Version 5.4
Mus musculus Gene: Vrk1
Summary
InnateDB Gene IDBG-169996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vrk1
Gene Name vaccinia related kinase 1
Synonyms 51PK
Species Mus musculus
Ensembl Gene ENSMUSG00000021115
Encoded Proteins
IDBP-169998
vaccinia related kinase 1
IDBP-170000
vaccinia related kinase 1
IDBP-170002
vaccinia related kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100749:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:106010263-106077410
Strand Forward strand
Band E
Transcripts
ENSMUST00000021539 ENSMUSP00000021539
ENSMUST00000085026 ENSMUSP00000082101
ENSMUST00000072040 ENSMUSP00000071922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031493 nucleosomal histone binding
GO:0035175 histone kinase activity (H3-S10 specific)
GO:0072354 histone kinase activity (H3-T3 specific)
Biological Process
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0043987 histone H3-S10 phosphorylation
GO:0046777 protein autophosphorylation
GO:0072355 histone H3-T3 phosphorylation
GO:0090166 Golgi disassembly
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005795 Golgi stack
GO:0005819 spindle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100749
View Gene Order
ENSBTAG00000014230
Not yet available
Pathways
NETPATH
REACTOME
REACT_196648
Nuclear Envelope Breakdown pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_208002
Nuclear Envelope Reassembly pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_210180
Initiation of Nuclear Envelope Reformation pathway
REACT_250557
Mitotic Prophase pathway
REACT_202512
Mitotic Anaphase pathway
REACT_221677
Clearance of Nuclear Envelope Membranes from Chromatin pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160251
Clearance of Nuclear Envelope Membranes from Chromatin pathway
REACT_160242
Initiation of Nuclear Envelope Reformation pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_765
Mitotic Prophase pathway
REACT_160113
Nuclear Envelope Reassembly pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q80X41
TrEMBL
UniProt Splice Variant
Entrez Gene 22367
UniGene Mm.2981 Mm.395433 Mm.408023
RefSeq NM_001029844 XM_006515815 NM_001029843 NM_011705 XM_006515807 XM_006515808 XM_006515809 XM_006515810 XM_006515811 XM_006515812 XM_006515814 XM_006515817 XM_006515818
OMIM
CCDS CCDS26158 CCDS26157 CCDS36551
HPRD
IMGT
MGI ID MGI:1261847
MGI Symbol Vrk1
EMBL AF080252 AF080253 AK032344 AK088230 AK088674 BC016676
GenPept AAC29496 AAC29497 AAH16676 BAC27825 BAC40225 BAC40497
RNA Seq Atlas 22367

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca