InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vrk1

Summary

InnateDB Protein

IDBP-170002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vrk1

Protein Name

vaccinia related kinase 1

Synonyms

51PK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071922

InnateDB Gene

IDBG-169996 (Vrk1)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.

Disease Associations

Tissue Specificity

Highly expressed in testis. Expressed in liver, kidney and muscle. Weakly expressed in thymus, bone marrow and spleen. {ECO:0000269PubMed:12782311, ECO:0000269PubMed:9521809}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0046777	protein autophosphorylation
GO:0090166	Golgi disassembly

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005795	Golgi stack
GO:0005819	spindle

Protein Structure and Domains

PDB ID

MGI:1261847

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt