InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hif1an

Summary

InnateDB Gene

IDBG-170063.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hif1an

Gene Name

hypoxia-inducible factor 1, alpha subunit inhibitor

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036450

Encoded Proteins

IDBP-170065

hypoxia-inducible factor 1, alpha subunit inhibitor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24145445

[Homo sapiens] Regulation of IL1B-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways in a manner that is dependent upon the combinatorial blockade of both EGLN2 and HIF1AN.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166135:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:44562850-44576274

Strand

Forward strand

Band

Transcripts

ENSMUST00000040455	ENSMUSP00000035326
ENSMUST00000131032

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031406	carboxylic acid binding
GO:0036139	peptidyl-histidine dioxygenase activity
GO:0036140	peptidyl-asparagine 3-dioxygenase activity
GO:0042803	protein homodimerization activity
GO:0048037	cofactor binding
GO:0051059	NF-kappaB binding
GO:0071532	ankyrin repeat binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0036138	peptidyl-histidine hydroxylation
GO:0042264	peptidyl-aspartic acid hydroxylation
GO:0042265	peptidyl-asparagine hydroxylation
GO:0045663	positive regulation of myoblast differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0055114	oxidation-reduction process
GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia