InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HIF1AN

Summary

InnateDB Gene

IDBG-86613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIF1AN

Gene Name

hypoxia inducible factor 1, alpha subunit inhibitor

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000166135

Encoded Proteins

IDBP-86615

hypoxia inducible factor 1, alpha subunit inhibitor

IDBP-585809

hypoxia inducible factor 1, alpha subunit inhibitor

IDBP-595576

hypoxia inducible factor 1, alpha subunit inhibitor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24145445

Regulation of IL1B-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways in a manner that is dependent upon the combinatorial blockade of both EGLN2 and HIF1AN.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:100529072-100559998

Strand

Forward strand

Band

q24.31

Transcripts

ENST00000299163	ENSP00000299163
ENST00000478787
ENST00000533589	ENSP00000433360
ENST00000526476	ENSP00000432791
ENST00000528044

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019826	oxygen sensor activity
GO:0031406	carboxylic acid binding
GO:0036139	peptidyl-histidine dioxygenase activity
GO:0036140	peptidyl-asparagine 3-dioxygenase activity
GO:0042803	protein homodimerization activity
GO:0048037	cofactor binding
GO:0051059	NF-kappaB binding
GO:0071532	ankyrin repeat binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0036138	peptidyl-histidine hydroxylation
GO:0042264	peptidyl-aspartic acid hydroxylation
GO:0042265	peptidyl-asparagine hydroxylation
GO:0045087	innate immune response (InnateDB)
GO:0045663	positive regulation of myoblast differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0055114	oxidation-reduction process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia
GO:2001214	positive regulation of vasculogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000036450

View Gene Order

ENSBTAG00000000092

Not yet available

Pathways

NETPATH

REACTOME

REACT_121226

Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha pathway

REACT_120956

Cellular responses to stress pathway

REACT_120815

Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway

REACT_121311

Cellular response to hypoxia pathway

KEGG

INOH

PID NCI

hif2pathway

HIF-2-alpha transcription factor network

hif1apathway

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.500788 Hs.700958

RefSeq

NM_017902

HUGO

OMIM

CCDS

CCDS7498

HPRD

09426

IMGT

EMBL

GenPept

RNA Seq Atlas