Version 5.4
| Mus musculus Gene: Tuba4a | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-170381.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Tuba4a | ||||||||||||||||||||||
| Gene Name | tubulin, alpha 4A | ||||||||||||||||||||||
| Synonyms | M[a]4; Tuba4 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000026202 | ||||||||||||||||||||||
| Encoded Proteins |
tubulin, alpha 4A
tubulin, alpha 4A
tubulin, alpha 4A
tubulin, alpha 4A
tubulin, alpha 4A
tubulin, alpha 4A
tubulin, alpha 4A
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127824:
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. [provided by RefSeq, Jul 2008] Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 1:75214228-75219865 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | C4 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Platelet degranulation pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Gap junction trafficking and regulation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Hemostasis pathway
Separation of Sister Chromatids pathway
Recycling pathway of L1 pathway
Gap junction assembly pathway
Hedgehog 'off' state pathway
Resolution of Sister Chromatid Cohesion pathway
Loss of Nlp from mitotic centrosomes pathway
Membrane Trafficking pathway
Chaperonin-mediated protein folding pathway
Cell Cycle pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
M Phase pathway
Metabolism of proteins pathway
Recruitment of NuMA to mitotic centrosomes pathway
Post-chaperonin tubulin folding pathway pathway
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
Kinesins pathway
Factors involved in megakaryocyte development and platelet production pathway
Mitotic G2-G2/M phases pathway
MHC class II antigen presentation pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Protein folding pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Prometaphase pathway
Axon guidance pathway
Transport of connexons to the plasma membrane pathway
Regulation of PLK1 Activity at G2/M Transition pathway
L1CAM interactions pathway
Adaptive Immune System pathway
Developmental Biology pathway
Signaling by Hedgehog pathway
Response to elevated platelet cytosolic Ca2+ pathway
Gap junction trafficking pathway
Signal Transduction pathway
Formation of tubulin folding intermediates by CCT/TriC pathway
Mitotic Anaphase pathway
Translocation of GLUT4 to the plasma membrane pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
Centrosome maturation pathway
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| KEGG |
Gap junction pathway
Phagosome pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
TCR pathway
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| REACTOME |
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
Separation of Sister Chromatids pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Recruitment of NuMA to mitotic centrosomes pathway
Recruitment of mitotic centrosome proteins and complexes pathway
MHC class II antigen presentation pathway
Kinesins pathway
Factors involved in megakaryocyte development and platelet production pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Post-chaperonin tubulin folding pathway pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
Formation of tubulin folding intermediates by CCT/TriC pathway
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
Transport of connexons to the plasma membrane pathway
Gap junction assembly pathway
Translocation of GLUT4 to the plasma membrane pathway
Recycling pathway of L1 pathway
L1CAM interactions pathway
Protein folding pathway
Developmental Biology pathway
Signaling by Hedgehog pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
Gap junction trafficking pathway
Chaperonin-mediated protein folding pathway
Cell Cycle pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
Immune System pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
M Phase pathway
Mitotic Anaphase pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Gap junction trafficking and regulation pathway
Hemostasis pathway
Membrane Trafficking pathway
Mitotic Metaphase and Anaphase pathway
G2/M Transition pathway
Platelet degranulation pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
Recycling pathway of L1 pathway
Factors involved in megakaryocyte development and platelet production pathway
M Phase pathway
L1CAM interactions pathway
Separation of Sister Chromatids pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Anaphase pathway
Translocation of GLUT4 to the plasma membrane pathway
Hemostasis pathway
Immune System pathway
Cell Cycle, Mitotic pathway
Loss of Nlp from mitotic centrosomes pathway
Platelet activation, signaling and aggregation pathway
Mitotic G2-G2/M phases pathway
Response to elevated platelet cytosolic Ca2+ pathway
Kinesins pathway
Gap junction trafficking pathway
Cell Cycle pathway
Signal Transduction pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Gap junction assembly pathway
Chaperonin-mediated protein folding pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Hedgehog 'off' state pathway
Axon guidance pathway
MHC class II antigen presentation pathway
Metabolism of proteins pathway
Gap junction trafficking and regulation pathway
Recruitment of NuMA to mitotic centrosomes pathway
Protein folding pathway
Resolution of Sister Chromatid Cohesion pathway
Adaptive Immune System pathway
Signaling by Hedgehog pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Centrosome maturation pathway
Mitotic Prometaphase pathway
Transport of connexons to the plasma membrane pathway
Developmental Biology pathway
Formation of tubulin folding intermediates by CCT/TriC pathway
Membrane Trafficking pathway
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| KEGG |
Pathogenic Escherichia coli infection pathway
Gap junction pathway
Phagosome pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||
| RefSeq | NM_009447 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS35623 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||