InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Epha3

Summary

InnateDB Gene

IDBG-170437.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epha3

Gene Name

Eph receptor A3

Synonyms

AW492086; Cek4; End3; ETK1; Hek; Hek4; Mek4; Tyro4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052504

Encoded Proteins

IDBP-170439

Eph receptor A3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000044524:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:63543538-63864158

Strand

Reverse strand

Band

C1.3

Transcripts

ENSMUST00000064405

ENSMUSP00000066554

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0010976	positive regulation of neuron projection development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032319	regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0048013	ephrin receptor signaling pathway
GO:0051893	regulation of focal adhesion assembly
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005769	early endosome
GO:0005887	integral component of plasma membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000044524

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu04360

Axon guidance pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

REACT_228063

EPHA-mediated growth cone collapse pathway

REACT_228189

EPH-ephrin mediated repulsion of cells pathway

REACT_228170

EPH-Ephrin signaling pathway

KEGG

hsa04360

Axon guidance pathway

INOH

PID NCI

epha_fwdpathway

EPHA forward signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.1977

RefSeq

NM_010140

OMIM

CCDS

CCDS28264

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas