InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epha3

Summary

InnateDB Protein

IDBP-170439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epha3

Protein Name

Eph receptor A3

Synonyms

AW492086; Cek4; End3; ETK1; Hek; Hek4; Mek4; Tyro4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066554

InnateDB Gene

IDBG-170437 (Epha3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0010976	positive regulation of neuron projection development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032319	regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0048013	ephrin receptor signaling pathway
GO:0051893	regulation of focal adhesion assembly
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005769	early endosome
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

MGI:99612

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
IPR013761 Sterile alpha motif/pointed domain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM