Version 5.4
Mus musculus Gene: Snx27
Summary
InnateDB Gene IDBG-170458.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Snx27
Gene Name sorting nexin family member 27
Synonyms 5730552M22Rik; ESTM45; ESTM47; R75405
Species Mus musculus
Ensembl Gene ENSMUSG00000028136
Encoded Proteins
IDBP-170460
sorting nexin family member 27
IDBP-266998
sorting nexin family member 27
IDBP-267000
sorting nexin family member 27
IDBP-536640
sorting nexin family member 27
IDBP-542670
sorting nexin family member 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 17577583
[Homo sapiens] SNX27 co-localizes with CYTIP at the early endosomal compartment of lymphocytes suggesting a role for this interaction in endocytic trafficking and/or signalling
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143376:
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:94497544-94582716
Strand Reverse strand
Band F2.1
Transcripts
ENSMUST00000029783 ENSMUSP00000029783
ENSMUST00000107283 ENSMUSP00000102904
ENSMUST00000107281 ENSMUSP00000102902
ENSMUST00000143860 ENSMUSP00000117930
ENSMUST00000140176 ENSMUSP00000119233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0008333 endosome to lysosome transport
GO:0016197 endosomal transport
GO:1990126 retrograde transport, endosome to plasma membrane
Cellular Component
GO:0001772 immunological synapse
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0030904 retromer complex
GO:0031901 early endosome membrane
GO:0071203 WASH complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143376
View Gene Order
ENSBTAG00000001942
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28160 Mm.396743 Mm.397218 Mm.474655
RefSeq NM_001082484 NM_029721
OMIM
CCDS CCDS38537 CCDS38538
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca