Version 5.4
Bos taurus Gene: SNX27
Summary
InnateDB Gene IDBG-633056.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX27
Gene Name Sorting nexin-27
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001942
Encoded Proteins
IDBP-684722
Sorting nexin-27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 17577583
[Homo sapiens] SNX27 co-localizes with CYTIP at the early endosomal compartment of lymphocytes suggesting a role for this interaction in endocytic trafficking and/or signalling
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143376:
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:19128462-19204626
Strand Reverse strand
Band
Transcripts
ENSBTAT00000033845 ENSBTAP00000033754
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:1990126 retrograde transport, endosome to plasma membrane
Cellular Component
GO:0001772 immunological synapse
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0030904 retromer complex
GO:0031901 early endosome membrane
GO:0071203 WASH complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143376
View Gene Order
ENSMUSG00000028136
View Gene Order
Cross-References
SwissProt A5PKA5
TrEMBL
UniProt Splice Variant
Entrez Gene 513214
UniGene Bt.39730
RefSeq NM_001098956
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142417
GenPept AAI42418
RNA Seq Atlas 513214

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca