InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rasa1

Summary

InnateDB Gene

IDBG-170464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasa1

Gene Name

RAS p21 protein activator 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021549

Encoded Proteins

IDBP-262152

RAS p21 protein activator 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145715:
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:85214780-85289029

Strand

Reverse strand

Band

Transcripts

ENSMUST00000109552	ENSMUSP00000105179
ENSMUST00000146792
ENSMUST00000142285
ENSMUST00000148014
ENSMUST00000149799
ENSMUST00000152466
ENSMUST00000141879
ENSMUST00000153231
ENSMUST00000132711

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0051020	GTPase binding

Biological Process

GO:0001953	negative regulation of cell-matrix adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0030833	regulation of actin filament polymerization
GO:0032320	positive regulation of Ras GTPase activity
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane