InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasa1

Summary

InnateDB Protein

IDBP-262152.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Rasa1

Protein Name

RAS p21 protein activator 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105179

InnateDB Gene

IDBG-170464 (Rasa1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0051020	GTPase binding

Biological Process

GO:0001953	negative regulation of cell-matrix adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0030833	regulation of actin filament polymerization
GO:0032320	positive regulation of Ras GTPase activity
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane

Protein Structure and Domains

PDB ID

MGI:97860

InterPro

IPR000008 C2 domain
IPR000980 SH2 domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein

PFAM