Version 5.4
Mus musculus Gene: Csk
Summary
InnateDB Gene IDBG-170552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Csk
Gene Name c-src tyrosine kinase
Synonyms AW212630
Species Mus musculus
Ensembl Gene ENSMUSG00000032312
Encoded Proteins
IDBP-170554
c-src tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 15749833
[Homo sapiens] Plays a critical role in IL-1-induced NF-kappaB activation through the IKK complex
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103653:
Gene Information
Type Protein coding
Genomic Location Chromosome 9:57626647-57645653
Strand Reverse strand
Band B
Transcripts
ENSMUST00000034863 ENSMUSP00000034863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0070064 proline-rich region binding
Biological Process
GO:0002376 immune system process
GO:0006468 protein phosphorylation
GO:0007420 brain development
GO:0008285 negative regulation of cell proliferation
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032715 negative regulation of interleukin-6 production
GO:0033673 negative regulation of kinase activity
GO:0034332 adherens junction organization
GO:0035556 intracellular signal transduction
GO:0042997 negative regulation of Golgi to plasma membrane protein transport
GO:0043406 positive regulation of MAP kinase activity
GO:0045779 negative regulation of bone resorption
GO:0046777 protein autophosphorylation
GO:0048709 oligodendrocyte differentiation
GO:0050765 negative regulation of phagocytosis
GO:0050863 regulation of T cell activation
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071375 cellular response to peptide hormone stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103653
View Gene Order
ENSBTAG00000021424
Not yet available
Pathways
NETPATH
REACTOME
REACT_263643
PD-1 signaling pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_216080
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_242976
Signaling by EGFR pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_229531
Adaptive Immune System pathway
REACT_206286
GAB1 signalosome pathway
REACT_188257
Signal Transduction pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
REACT_222648
TCR signaling pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_12
BCR pathway
REACTOME
REACT_12582
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_12526
TCR signaling pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_208036
Signaling by EGFR pathway
REACT_222082
GAB1 signalosome pathway
REACT_213223
PD-1 signaling pathway
REACT_212961
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_213843
Costimulation by the CD28 family pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_217199
Platelet Aggregation (Plug Formation) pathway
REACT_214353
Signal Transduction pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_206808
Integrin alphaIIb beta3 signaling pathway
REACT_214469
Adaptive Immune System pathway
REACT_207087
Disease pathway
REACT_213465
TCR signaling pathway
KEGG
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cxcr4_pathway
CXCR4-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
ptp1bpathway
Signaling events mediated by PTP1B
bcr_5pathway
BCR signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt P41241
TrEMBL
UniProt Splice Variant
Entrez Gene 12988
UniGene Mm.21974 Mm.470150
RefSeq NM_007783 XM_006510801 XM_006510802 XM_006510803
OMIM
CCDS CCDS23228
HPRD
IMGT
MGI ID MGI:88537
MGI Symbol Csk
EMBL AK156058 AK170815 AY902339 BC018394 BC052006 U05247 X57242
GenPept AAA18766 AAH18394 AAH52006 AAX90624 BAE33565 BAE42047 CAA40518
RNA Seq Atlas 12988

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca