InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wnt7b

Summary

InnateDB Gene

IDBG-170604.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt7b

Gene Name

wingless-related MMTV integration site 7B

Synonyms

Wnt-7b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022382

Encoded Proteins

IDBP-170606

wingless-related MMTV integration site 7B

IDBP-262415

wingless-related MMTV integration site 7B

IDBP-624267

wingless-related MMTV integration site 7B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188064:
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:85535439-85581821

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023015	ENSMUSP00000023015
ENSMUST00000109424	ENSMUSP00000105051
ENSMUST00000167968	ENSMUSP00000130627

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0048018	receptor agonist activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001944	vasculature development
GO:0003338	metanephros morphogenesis
GO:0007165	signal transduction
GO:0007257	activation of JUN kinase activity
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0016332	establishment or maintenance of polarity of embryonic epithelium
GO:0021846	cell proliferation in forebrain
GO:0021871	forebrain regionalization
GO:0022009	central nervous system vasculogenesis
GO:0030182	neuron differentiation
GO:0030324	lung development
GO:0031175	neuron projection development
GO:0032364	oxygen homeostasis
GO:0032536	regulation of cell projection size
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042592	homeostatic process
GO:0044237	cellular metabolic process
GO:0045165	cell fate commitment
GO:0045669	positive regulation of osteoblast differentiation
GO:0045879	negative regulation of smoothened signaling pathway
GO:0046330	positive regulation of JNK cascade
GO:0048144	fibroblast proliferation
GO:0048568	embryonic organ development
GO:0048812	neuron projection morphogenesis
GO:0048864	stem cell development
GO:0050768	negative regulation of neurogenesis
GO:0050808	synapse organization
GO:0051145	smooth muscle cell differentiation
GO:0051384	response to glucocorticoid
GO:0060033	anatomical structure regression
GO:0060070	canonical Wnt signaling pathway
GO:0060425	lung morphogenesis
GO:0060428	lung epithelium development
GO:0060482	lobar bronchus development
GO:0060484	lung-associated mesenchyme development
GO:0060535	trachea cartilage morphogenesis
GO:0060560	developmental growth involved in morphogenesis
GO:0060669	embryonic placenta morphogenesis
GO:0060710	chorio-allantoic fusion
GO:0061180	mammary gland epithelium development
GO:0071300	cellular response to retinoic acid
GO:0072053	renal inner medulla development
GO:0072054	renal outer medulla development
GO:0072060	outer medullary collecting duct development
GO:0072061	inner medullary collecting duct development
GO:0072089	stem cell proliferation
GO:0072205	metanephric collecting duct development
GO:0072207	metanephric epithelium development
GO:0072236	metanephric loop of Henle development
GO:1902262	apoptotic process involved in patterning of blood vessels

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005886	plasma membrane
GO:0009986	cell surface