InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vcan

Summary

InnateDB Gene

IDBG-170883.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vcan

Gene Name

versican

Synonyms

5430420N07Rik; 9430051N09; Cspg2; DPEAAE; hdf; NG2; PG-M; PG-M(V0); PG-M(V1)

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021614

Encoded Proteins

IDBP-262163

versican

IDBP-262167

versican

IDBP-262169

versican

IDBP-531520

versican

IDBP-536284

versican

IDBP-541888

versican

IDBP-538352

versican

IDBP-532423

versican

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000038427:
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:89655312-89742509

Strand

Reverse strand

Band

Transcripts

ENSMUST00000109546	ENSMUSP00000105173
ENSMUST00000109544	ENSMUSP00000105171
ENSMUST00000109543	ENSMUSP00000105170
ENSMUST00000159910	ENSMUSP00000125446
ENSMUST00000160740	ENSMUSP00000125694
ENSMUST00000159285	ENSMUSP00000125674
ENSMUST00000160029
ENSMUST00000159337	ENSMUSP00000125432
ENSMUST00000162715	ENSMUSP00000125521

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0030246	carbohydrate binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0007155	cell adhesion
GO:0007507	heart development
GO:0008347	glial cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000038427

View Gene Order

ENSBTAG00000014906

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_120800

Dermatan sulfate biosynthesis pathway

REACT_121408

A tetrasaccharide linker sequence is required for GAG synthesis pathway

REACT_120888

CS/DS degradation pathway

REACT_120989

Chondroitin sulfate biosynthesis pathway

REACT_147853

Mucopolysaccharidoses pathway

REACT_200783

Myoclonic epilepsy of Lafora pathway

REACT_118779

Extracellular matrix organization pathway

REACT_267711

Defective B4GALT7 causes EDS, progeroid type pathway

REACT_267713

Defective CHST6 causes MCDC1 pathway

REACT_147719

MPS VI - Maroteaux-Lamy syndrome pathway

REACT_267645

Defective PAPSS2 causes SEMD-PA pathway

REACT_474

Metabolism of carbohydrates pathway

REACT_147749

MPS IIID - Sanfilippo syndrome D pathway

REACT_267662

Defective SLC26A2 causes chondrodysplasias pathway

REACT_147739

MPS IX - Natowicz syndrome pathway

REACT_267674

Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway

REACT_267642

Defective CHST14 causes EDS, musculocontractural type pathway

REACT_121314

Heparan sulfate/heparin (HS-GAG) metabolism pathway

REACT_147798

MPS IV - Morquio syndrome B pathway

REACT_163906

ECM proteoglycans pathway

REACT_267659

Defective B3GAT3 causes JDSSDHD pathway

REACT_267708

Defective CHST3 causes SEDCJD pathway

REACT_147825

MPS IV - Morquio syndrome A pathway

REACT_267654

Defective EXT2 causes exostoses 2 pathway

REACT_267707

Diseases associated with glycosaminoglycan metabolism pathway

REACT_147734

MPS II - Hunter syndrome pathway

REACT_267635

Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway

REACT_121315

Glycosaminoglycan metabolism pathway

REACT_267705

Diseases of glycosylation pathway

REACT_121206

Chondroitin sulfate/dermatan sulfate metabolism pathway

REACT_147759

MPS VII - Sly syndrome pathway

REACT_267682

Defective CHSY1 causes TPBS pathway

REACT_111217

Metabolism pathway

REACT_147857

MPS I - Hurler syndrome pathway

REACT_147753

MPS IIIA - Sanfilippo syndrome A pathway

REACT_147860

MPS IIIC - Sanfilippo syndrome C pathway

REACT_116125

Disease pathway

REACT_200833

Glycogen storage diseases pathway

REACT_147788

MPS IIIB - Sanfilippo syndrome B pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

INOH

INOH website

Integrin signaling pathway pathway

PID NCI

p53downstreampathway

Direct p53 effectors

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

toll_endogenous_pathway

Endogenous TLR signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.158700 Mm.405032

RefSeq

NM_001081249 NM_001134474 NM_001134475 NM_019389 NM_172955 XM_006517076 XM_006517077 XM_006517078 XM_006517079

OMIM

CCDS

CCDS36740 CCDS49321 CCDS49322 CCDS49323 CCDS49324

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas