InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRPV3

Summary

InnateDB Gene

IDBG-17119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPV3

Gene Name

transient receptor potential cation channel, subfamily V, member 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000167723

Encoded Proteins

IDBP-17121

transient receptor potential cation channel, subfamily V, member 3

IDBP-17123

transient receptor potential cation channel, subfamily V, member 3

IDBP-761758

IDBP-757984

IDBP-761181

IDBP-758220

IDBP-758394

IDBP-810470

transient receptor potential cation channel, subfamily V, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:3510502-3557995

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000381913	ENSP00000371338
ENST00000301365	ENSP00000301365
ENST00000571005
ENST00000574773
ENST00000575865
ENST00000576742	ENSP00000461518
ENST00000573539	ENSP00000458239
ENST00000577016	ENSP00000460856
ENST00000572519	ENSP00000460215
ENST00000571139	ENSP00000458187
ENST00000616411	ENSP00000483947

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0009266	response to temperature stimulus
GO:0009408	response to heat
GO:0034220	ion transmembrane transport
GO:0042636	negative regulation of hair cycle
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0090280	positive regulation of calcium ion import

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000043029

View Gene Order

ENSBTAG00000000020

Not yet available

Pathways

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

REACT_169333

TRP channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.619949

RefSeq

NM_001258205 NM_145068

HUGO

OMIM

CCDS

CCDS11029 CCDS58500

HPRD

06141

IMGT

EMBL

GenPept

RNA Seq Atlas