InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trpv3

Summary

InnateDB Gene

IDBG-198087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpv3

Gene Name

transient receptor potential cation channel, subfamily V, member 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000043029

Encoded Proteins

IDBP-198089

transient receptor potential cation channel, subfamily V, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167723:
This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:73267388-73300363

Strand

Forward strand

Band

Transcripts

ENSMUST00000049676

ENSMUSP00000053755

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0009266	response to temperature stimulus
GO:0009408	response to heat
GO:0042636	negative regulation of hair cycle
GO:0070588	calcium ion transmembrane transport
GO:0090280	positive regulation of calcium ion import

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000167723

View Gene Order

ENSBTAG00000000020

Not yet available

Pathways

NETPATH

REACTOME

REACT_196640

Stimuli-sensing channels pathway

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_227861

TRP channels pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

REACT_169333

TRP channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q8K424

TrEMBL

UniProt Splice Variant

Entrez Gene

246788

UniGene

Mm.347652 Mm.75196

RefSeq

NM_145099 XM_006533347 XM_006533348 XM_006536295

OMIM

CCDS

CCDS25004

HPRD

IMGT

MGI ID

MGI:2181407

MGI Symbol

Trpv3

EMBL

AF510316 AL645739

GenPept

AAM33069 CAI24566

RNA Seq Atlas

246788