Version 5.4
Mus musculus Gene: Prtn3
Summary
InnateDB Gene IDBG-171313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prtn3
Gene Name proteinase 3
Synonyms mPR3; PR3
Species Mus musculus
Ensembl Gene ENSMUSG00000057729
Encoded Proteins
IDBP-171315
proteinase 3
IDBP-621511
proteinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24129891
[Homo sapiens] IL32 interacts with PRTN2 (PR3) and F2RL1, triggering the PAR2-TRIF signalling axis, and IL32 may have a potential role in the transition from innate to adaptive immunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196415:
Gene Information
Type Protein coding
Genomic Location Chromosome 10:79874476-79883174
Strand Forward strand
Band C1
Transcripts
ENSMUST00000006679 ENSMUSP00000006679
ENSMUST00000163188
ENSMUST00000165982
ENSMUST00000164134
ENSMUST00000166201 ENSMUSP00000129585
ENSMUST00000171489
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0019899 enzyme binding
Biological Process
GO:0006508 proteolysis
GO:0030574 collagen catabolic process
GO:0050765 negative regulation of phagocytosis
GO:0097029 mature dendritic cell differentiation
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196415
View Gene Order
ENSBTAG00000046105
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.2364
RefSeq NM_011178
OMIM
CCDS CCDS23993
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca