InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vps72

Summary

InnateDB Gene

IDBG-171412.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps72

Gene Name

vacuolar protein sorting 72 (yeast)

Synonyms

Tcfl1; YL-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000008958

Encoded Proteins

IDBP-171414

vacuolar protein sorting 72 (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163159:
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:95111022-95123051

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000009102	ENSMUSP00000009102
ENSMUST00000136076
ENSMUST00000125548
ENSMUST00000139296
ENSMUST00000152333

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0035019	somatic stem cell maintenance

Cellular Component

GO:0005634	nucleus
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000163159

View Gene Order

ENSBTAG00000018074

Not yet available

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_226917

HATs acetylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_207632

Chromatin organization pathway

REACT_219482

HATs acetylate histones pathway

REACT_227044

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.133919 Mm.467327

RefSeq

NM_009336 XM_006501291

OMIM

CCDS

CCDS38543

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas