Mus musculus Gene: Cfd | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-171424.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Cfd | ||||||||||||||||||||||
Gene Name | complement factor D (adipsin) | ||||||||||||||||||||||
Synonyms | Adn; DF | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000061780 | ||||||||||||||||||||||
Encoded Proteins |
complement factor D (adipsin)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197766:
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 10:79890853-79892656 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | C1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Platelet degranulation pathway
Innate Immune System pathway
Complement cascade pathway
Hemostasis pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Alternative complement activation pathway
Initial triggering of complement pathway
Response to elevated platelet cytosolic Ca2+ pathway
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KEGG |
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Alternative complement activation pathway
Initial triggering of complement pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Immune System pathway
Complement cascade pathway
Hemostasis pathway
Platelet degranulation pathway
Initial triggering of complement pathway
Hemostasis pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Alternative complement activation pathway
Complement cascade pathway
Innate Immune System pathway
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KEGG |
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P03953 | ||||||||||||||||||||||
TrEMBL | B7ZNS9 Q3UP47 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 11537 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_001291915 NM_013459 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS23995 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:87931 | ||||||||||||||||||||||
MGI Symbol | Cfd | ||||||||||||||||||||||
EMBL | AK143817 BC138778 BC138779 BC145412 CH466553 M11768 M13386 X04673 | ||||||||||||||||||||||
GenPept | AAA37262 AAA40486 AAI38779 AAI38780 AAI45413 BAE25550 CAA28378 CAA28379 EDL31632 EDL31634 | ||||||||||||||||||||||
RNA Seq Atlas | 11537 | ||||||||||||||||||||||