Version 5.4
Bos taurus Gene: CFD
Summary
InnateDB Gene IDBG-645537.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFD
Gene Name Complement factor D
Synonyms DF
Species Bos taurus
Ensembl Gene ENSBTAG00000048122
Encoded Proteins
IDBP-698244
Complement factor D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197766:
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:45030310-45032845
Strand Forward strand
Band
Transcripts
ENSBTAT00000063284 ENSBTAP00000055802
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0002376 immune system process
GO:0006508 proteolysis
GO:0006957 complement activation, alternative pathway
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000197766
View Gene Order
ENSMUSG00000061780
View Gene Order
Pathways
NETPATH
REACTOME
REACT_202252
Platelet degranulation pathway
REACT_218492
Initial triggering of complement pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_205632
Alternative complement activation pathway
REACT_209085
Complement cascade pathway
REACT_216714
Innate Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_8001
Alternative complement activation pathway
REACT_8024
Initial triggering of complement pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
REACT_604
Hemostasis pathway
REACT_230203
Platelet degranulation pathway
REACT_239142
Innate Immune System pathway
REACT_208792
Complement cascade pathway
REACT_224553
Hemostasis pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_218037
Alternative complement activation pathway
REACT_202834
Initial triggering of complement pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05150
Staphylococcus aureus infection pathway
mmu04610
Complement and coagulation cascades pathway
mmu05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Cross-References
SwissProt Q3T0A3
TrEMBL
UniProt Splice Variant
Entrez Gene 505647
UniGene Bt.41326
RefSeq NM_001034255 XM_005209262
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102479
GenPept AAI02480
RNA Seq Atlas 505647
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca