Version 5.4
Mus musculus Gene: Usf2
Summary
InnateDB Gene IDBG-171814.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usf2
Gene Name upstream transcription factor 2
Synonyms bHLHb12; Usf-2
Species Mus musculus
Ensembl Gene ENSMUSG00000058239
Encoded Proteins
IDBP-626347
upstream transcription factor 2
IDBP-626357
upstream transcription factor 2
IDBP-541510
upstream transcription factor 2
IDBP-626349
upstream transcription factor 2
IDBP-626355
upstream transcription factor 2
IDBP-626358
upstream transcription factor 2
IDBP-626362
upstream transcription factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105698:
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30945252-30956803
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000058860 ENSMUSP00000132256
ENSMUST00000108119 ENSMUSP00000132021
ENSMUST00000162228 ENSMUSP00000125520
ENSMUST00000167285
ENSMUST00000170442 ENSMUSP00000130298
ENSMUST00000171338
ENSMUST00000170699 ENSMUSP00000127908
ENSMUST00000172417 ENSMUSP00000132833
ENSMUST00000169496
ENSMUST00000166340 ENSMUSP00000132232
ENSMUST00000168731
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007595 lactation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055088 lipid homeostasis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105698
View Gene Order
ENSBTAG00000017035
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.322453 Mm.466352 Mm.468863
RefSeq NM_011680 XM_006539735
OMIM
CCDS CCDS21118
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca