Version 5.4
Mus musculus Protein: Usf2
Summary
InnateDB Protein IDBP-541510.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usf2
Protein Name upstream transcription factor 2
Synonyms bHLHb12; Usf-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000125520
InnateDB Gene IDBG-171814 (Usf2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003702 RNA polymerase II transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0016563 transcription activator activity
GO:0030528 transcription regulator activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007595 lactation
GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
GO:0045449 regulation of transcription
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045941 positive regulation of transcription
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055088 lipid homeostasis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:99961
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F8WI12
UniProt Splice Variant
Entrez Gene 22282
UniGene Mm.468863
RefSeq XP_006539797
MGI ID
MGI Symbol Usf2
OMIM
CCDS
HPRD
IMGT
EMBL AC149055
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca