InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Loxl1

Summary

InnateDB Gene

IDBG-171902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Loxl1

Gene Name

lysyl oxidase-like 1

Synonyms

Loxl

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032334

Encoded Proteins

IDBP-171906

lysyl oxidase-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129038:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:58287723-58313212

Strand

Reverse strand

Band

Transcripts

ENSMUST00000061799

ENSMUSP00000057406

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process

GO:0032496	response to lipopolysaccharide
GO:0035904	aorta development
GO:0055114	oxidation-reduction process

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031012	extracellular matrix