InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LOXL1

Summary

InnateDB Gene

IDBG-21345.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LOXL1

Gene Name

lysyl oxidase-like 1

Synonyms

LOL; LOXL

Species

Homo sapiens

Ensembl Gene

ENSG00000129038

Encoded Proteins

IDBP-21347

lysyl oxidase-like 1

IDBP-746156

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:73925989-73952137

Strand

Forward strand

Band

q24.1

Transcripts

ENST00000261921	ENSP00000261921
ENST00000566530
ENST00000567675
ENST00000562548
ENST00000566011	ENSP00000457827

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process

GO:0018277	protein deamination
GO:0030198	extracellular matrix organization
GO:0032496	response to lipopolysaccharide
GO:0035904	aorta development
GO:0055114	oxidation-reduction process

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031012	extracellular matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032334

View Gene Order

ENSBTAG00000009086

Not yet available

Pathways

NETPATH

REACTOME

REACT_150206

Crosslinking of collagen fibrils pathway

REACT_150180

Assembly of collagen fibrils and other multimeric structures pathway

REACT_150366

Elastic fibre formation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_120729

Collagen formation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q08397

TrEMBL

H3BUV8

UniProt Splice Variant

Entrez Gene

4016

UniGene

Hs.598750 Hs.65436

RefSeq

NM_005576

HUGO

HGNC:6665

OMIM

153456

CCDS

CCDS10253

HPRD

IMGT

EMBL

AC108137 AK314222 BC015090 BC068542 L21186 U24389 U24390 U24391 U24393 U24394 U24395

GenPept

AAA50162 AAA68940 AAH15090 AAH68542 BAG36895

RNA Seq Atlas

4016