Mus musculus Gene: Dhfr | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-172010.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Dhfr | ||||||||||||||||||||||
Gene Name | dihydrofolate reductase | ||||||||||||||||||||||
Synonyms | 8430436I03Rik; AA607882; AI662710; AW555094 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000021707 | ||||||||||||||||||||||
Encoded Proteins |
dihydrofolate reductase
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000228716:
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. [provided by RefSeq, Jul 2008] Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 13:92354783-92389053 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | C3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Cell Cycle, Mitotic pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Disease pathway
eNOS activation and regulation pathway
Cell Cycle pathway
Metabolism pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective GIF causes intrinsic factor deficiency pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective CD320 causes methylmalonic aciduria pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defects in biotin (Btn) metabolism pathway
Defective BTD causes biotidinase deficiency pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Metabolism of vitamins and cofactors pathway
G1/S-Specific Transcription pathway
Metabolism of folate and pterines pathway
Metabolism of nitric oxide pathway
Metabolism of water-soluble vitamins and cofactors pathway
E2F mediated regulation of DNA replication pathway
Defects in vitamin and cofactor metabolism pathway
Defects in cobalamin (B12) metabolism pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Defective HLCS causes multiple carboxylase deficiency pathway
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KEGG |
Folate biosynthesis pathway
One carbon pool by folate pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
Metabolism of folate and pterines pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
eNOS activation and regulation pathway
Mitotic G1-G1/S phases pathway
Metabolism of water-soluble vitamins and cofactors pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Metabolism of nitric oxide pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Defective CD320 causes methylmalonic aciduria pathway
G1/S Transition pathway
Defects in cobalamin (B12) metabolism pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Cell Cycle pathway
Defects in biotin (Btn) metabolism pathway
Defective BTD causes biotidinase deficiency pathway
Defective GIF causes intrinsic factor deficiency pathway
Defects in vitamin and cofactor metabolism pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Cell Cycle, Mitotic pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Metabolism pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Disease pathway
Metabolism of vitamins and cofactors pathway
Metabolism of folate and pterines pathway
Defective GIF causes intrinsic factor deficiency pathway
Defects in cobalamin (B12) metabolism pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Mitotic G1-G1/S phases pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defects in vitamin and cofactor metabolism pathway
eNOS activation and regulation pathway
Defects in biotin (Btn) metabolism pathway
Metabolism of nitric oxide pathway
G1/S Transition pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Cell Cycle, Mitotic pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
E2F mediated regulation of DNA replication pathway
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Cell Cycle pathway
Defective BTD causes biotidinase deficiency pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Defective CD320 causes methylmalonic aciduria pathway
Metabolism of water-soluble vitamins and cofactors pathway
Metabolism of vitamins and cofactors pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Metabolism pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
G1/S-Specific Transcription pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Disease pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
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KEGG |
One carbon pool by folate pathway
Folate biosynthesis pathway
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INOH |
Folate metabolism pathway
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PID NCI |
E2F transcription factor network
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Cross-References | |||||||||||||||||||||||
SwissProt | P00375 | ||||||||||||||||||||||
TrEMBL | Q544T5 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 13361 | ||||||||||||||||||||||
UniGene | Mm.23695 Mm.471584 | ||||||||||||||||||||||
RefSeq | NM_010049 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS26680 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:94890 | ||||||||||||||||||||||
MGI Symbol | Dhfr | ||||||||||||||||||||||
EMBL | AK031241 AK136212 BC005796 CH466567 J00382 J00383 J00384 J00385 J00386 J00387 L26316 M10071 M10722 M10811 V00731 V00733 V00734 X56066 | ||||||||||||||||||||||
GenPept | AAA37523 AAA37524 AAA37525 AAA37637 AAA37638 AAH05796 BAC27315 BAE22879 CAA24111 CAA24112 CAA39544 CAB43539 EDL00958 | ||||||||||||||||||||||
RNA Seq Atlas | 13361 | ||||||||||||||||||||||