InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhfr

Summary

InnateDB Protein

IDBP-172012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhfr

Protein Name

dihydrofolate reductase

Synonyms

8430436I03Rik; AA607882; AI662710; AW555094;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022218

InnateDB Gene

IDBG-172010 (Dhfr)

Protein Structure

UniProt Annotation

Function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0004146	dihydrofolate reductase activity
GO:0008144	drug binding
GO:0050661	NADP binding
GO:0051871	dihydrofolic acid binding

Biological Process

GO:0006545	glycine biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0009165	nucleotide biosynthetic process
GO:0031427	response to methotrexate
GO:0035094	response to nicotine
GO:0046452	dihydrofolate metabolic process
GO:0046653	tetrahydrofolate metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0055114	oxidation-reduction process