Version 5.4
Mus musculus Gene: Il4
Summary
InnateDB Gene IDBG-172024.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il4
Gene Name interleukin 4
Synonyms BSF-1; Il-4
Species Mus musculus
Ensembl Gene ENSMUSG00000000869
Encoded Proteins
IDBP-172026
interleukin 4
IDBP-623766
interleukin 4
IDBP-623764
interleukin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21566158
Exogenous Il4 was sufficient to drive the accumulation of tissue macrophages through self-renewal revealing that the expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells.
PMID 23991011
IL4 attenuates Th1-chemokines expression at the site of inflammation reducing Th1 lymphocyte recruitment and limits pathogen clearance
PMID 25888258
Nlrp12 is an intrinsic negative regulator of T-cell-mediated immunity. Altered NF-kB regulation and Il4 production are key mediators of Nlrp12-associated disease.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:53602982-53618669
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000000889 ENSMUSP00000000889
ENSMUST00000127858
ENSMUST00000140684 ENSMUSP00000133617
ENSMUST00000150568 ENSMUSP00000134414
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 2 [view]
Protein-DNA 22 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005136 interleukin-4 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001774 microglial cell activation
GO:0001934 positive regulation of protein phosphorylation
GO:0002227 innate immune response in mucosa
GO:0002230 positive regulation of defense response to virus by host
GO:0002296 T-helper 1 cell lineage commitment
GO:0002674 negative regulation of acute inflammatory response
GO:0002677 negative regulation of chronic inflammatory response
GO:0006955 immune response
GO:0007565 female pregnancy
GO:0007584 response to nutrient
GO:0008203 cholesterol metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0010155 regulation of proton transport
GO:0014070 response to organic cyclic compound
GO:0030890 positive regulation of B cell proliferation
GO:0031296 B cell costimulation
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0034097 response to cytokine
GO:0035745 T-helper 2 cell cytokine production
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042113 B cell activation
GO:0042493 response to drug
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832 defense response to protozoan
GO:0043031 negative regulation of macrophage activation
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045064 T-helper 2 cell differentiation
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045471 response to ethanol
GO:0045582 positive regulation of T cell differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048295 positive regulation of isotype switching to IgE isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050868 negative regulation of T cell activation
GO:0050871 positive regulation of B cell activation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060041 retina development in camera-type eye
GO:0071288 cellular response to mercury ion
GO:0071677 positive regulation of mononuclear cell migration
GO:0097028 dendritic cell differentiation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000320 negative regulation of T-helper 17 cell differentiation
GO:2000424 positive regulation of eosinophil chemotaxis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu05310
Asthma pathway
mmu05330
Allograft rejection pathway
mmu05320
Autoimmune thyroid disease pathway
mmu04672
Intestinal immune network for IgA production pathway
mmu05140
Leishmaniasis pathway
INOH
INOH website
IL-4 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-13 signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.276360
RefSeq NM_021283
OMIM
CCDS CCDS24682
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca