Version 5.4
Mus musculus Protein: Il4
Summary
InnateDB Protein IDBP-623766.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il4
Protein Name interleukin 4
Synonyms BSF-1; Il-4;
Species Mus musculus
Ensembl Protein ENSMUSP00000133617
InnateDB Gene IDBG-172024 (Il4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 2 [view]
Protein-DNA 22 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005136 interleukin-4 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002296 T-helper 1 cell lineage commitment
GO:0002674 negative regulation of acute inflammatory response
GO:0002677 negative regulation of chronic inflammatory response
GO:0006955 immune response
GO:0007565 female pregnancy
GO:0007584 response to nutrient
GO:0010155 regulation of proton transport
GO:0014070 response to organic cyclic compound
GO:0030890 positive regulation of B cell proliferation
GO:0031296 B cell costimulation
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0034097 response to cytokine
GO:0035745 T-helper 2 cell cytokine production
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042113 B cell activation
GO:0042493 response to drug
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832 defense response to protozoan
GO:0043031 negative regulation of macrophage activation
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045064 T-helper 2 cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045471 response to ethanol
GO:0045582 positive regulation of T cell differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048295 positive regulation of isotype switching to IgE isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050868 negative regulation of T cell activation
GO:0050871 positive regulation of B cell activation
GO:0071288 cellular response to mercury ion
GO:0097028 dendritic cell differentiation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000320 negative regulation of T-helper 17 cell differentiation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:96556
InterPro IPR002354 Interleukin-4
IPR009079 Four-helical cytokine-like, core
PFAM PF00727
PRINTS PR00431
PIRSF PIRSF001941
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3UXB0
UniProt Splice Variant
Entrez Gene 16189
UniGene Mm.276360
RefSeq
MGI ID
MGI Symbol Il4
OMIM
CCDS
HPRD
IMGT
EMBL AL596095 AL645741 CH466575
GenPept EDL33577

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca